성견에서 골형성단백질이 코팅된 임플란트가 치조골 증대에 미치는 영향
Effect of rhPMP-2 coated implants on alveolar ridge augmentation in dogs
박찬경, 김종은, 신주희, 류재준, 허중보, 신상완,
소속 상세정보
박찬경 ( Park Chan-Kyung ) - 고려대학교 임상치의학연구소 임상치의학대학원 고급보철과
김종은 ( Kim Jong-Eun ) - 고려대학교 임상치의학대학원 고급치과보철학과
신주희 ( Shin Ju-Hee ) - 고려대학교 임상치의학대학원 고급치과보철학과
류재준 ( Ryu Jae-Jun ) - 고려대학교 임상치의학대학원
허중보 ( Huh Jung-Bo ) - 고려대학교 임상치의학연구소 임상치의학대학원 고급보철과
신상완 ( Shin Sang-Wan ) - 고려대학교 임상치의학연구소 임상치의학대학원 고급보철과
KMID : 0362420100480030202
Abstract
Purpose This study was aimed to evaluate the effect of rhPMP-2 coated implants on alveolar ridge augmentation in dogs.
Material and methods Six Beagle dogs were used in this study. Six 8.0 mm long anodized surface titanium implants were placed 5 mm into the mandibular alveolar ridge following 6 month of healing period after extraction. Each animal received three implants coated with rhBMP-2 and three uncoated control implants using the randomized split-mouth design. Radiographic examinations were undertaken i mmediately at implant placement (baseline), at weeks 4 and 8 after implant placement. The amount of bone augmentation was evaluated by measuring the distance from the uppermost point of the coverscrew to the marginal bone. Implant Stability Quotient (ISQ) values were measured i mmediately at implant placement and 8 weeks after implant placement. For the statistical analysis, Man-Whitney ranksum test and Wilcoxon signed rank test of SPSS 12.0 software were used (P = .05).
Results The BMP group exhibited radiographic vertical bone augmentation about 0.6 ± 0.7 mm at 8 weeks later while controls showed bone loss about 0.4 ± 0.6 mm. There was significant difference among the rhBMP-2 group and controls in bone level change (P < .05). The ISQ values were significantly higher in the BMP-2 group than the control group at 8 weeks later (P < .05), while there was no significant difference at surgery.
Conclusion Within the limitation of this study, the rhBMP-2 coated on anodized implant could stimulate vertical alveolar bone augmentation, which may increase implant stability significantly on completely healed alveolar ridge.
키워드
골형성단백질;임플란트;골유착;임플란트 안정도;골증대
rhBMP-2;implant;Osseointegration;Implant stability;Bone augmentation
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